How much does Medicare pay for CPT 88346?

Medicare allowed an average of $87.18 per service and paid $68.93 of that, the balance being the patient's coinsurance and deductible (2024 data). Providers submitted an average of $195.47, which is what they billed rather than what they received — Medicare pays its fee schedule regardless of the charge.

What is CPT code 88346?

Antibody evaluation, initial single antibody stain procedure. It was billed 56,912 times to 45,483 Medicare beneficiaries by 710 providers in 2024.

Does 88346 pay differently in an office than a hospital?

Yes. The allowed amount averaged $122.57 in an office setting and $34.42 in a facility. The office rate is generally higher because the practice supplies the room, staff and equipment out of that single payment; in a hospital those are billed separately by the facility.

Which specialty bills 88346 most?

Clinical Laboratory, with 27,560 services from 85 clinicians. Next are Pathology, Dermatology, Oral Surgery (Dentist only).

CPT 88346

Antibody evaluation, initial single antibody stain procedure

$87.18Medicare-allowed amount per service, averaged across 56,912 services

Providers submitted

$195.47

Asking price, not received

Medicare allowed

$87.18

The fee schedule figure

Medicare paid

$68.93

Balance is patient coinsurance

Providers submitted an average of $195.47 for this code and Medicare allowed $87.18 — 2.2× less. That gap is normal and means nothing on its own: Medicare pays its fee schedule regardless of what is billed, so the submitted figure describes a hospital chargemaster, not a price anyone paid. Of the allowed amount Medicare paid $68.93 (79%); the rest is the patient’s coinsurance and deductible.

Office pays differently to hospital

Office / non-facility: $122.57
Hospital / facility: $34.42

The office rate is higher because the practice supplies the room, staff and equipment out of that payment. In a hospital the facility bills those separately, so the clinician's share is smaller — the total cost to Medicare is usually higher, not lower. 34,063 services were billed in an office setting and 22,849 in a facility.

Services: 56,912
Beneficiaries: 45,483
Providers billing it: 710
Total allowed: $4,961,588

What Medicare pays for CPT 88346

Across 56,912 services billed by 710 providers to 45,483 beneficiaries, Medicare allowed an average of $87.18 per service. That is 1.3 services per beneficiary, so this is a code patients typically receive more than once. The allowed amount is the figure that matters: it is what Medicare and the patient together owe, set by the fee schedule and adjusted for local practice costs. What a provider chose to submit has no bearing on it.

Who bills 88346

Specialty	Services	Beneficiaries	Avg allowed	Providers
Clinical Laboratory	27,560	19,045	$116.63	85
Pathology	25,438	22,926	$55.09	519
Dermatology	3,384	3,118	$89.02	92
Oral Surgery (Dentist only)	212	208	$120.90	6
Hematopoietic Cell Transplantation and Cellular Therapy	139	20	$33.09	1
Undefined Physician type	88	81	$40.14	1
Ophthalmology	38	34	$183.10	2
Dentist	27	26	$36.62	2
Maxillofacial Surgery	14	13	$176.28	1
Hematology	12	12	$39.88	1

88346 reimbursement by state

Two different numbers. Allowed is what Medicare actually allowed in that state, which includes the local practice-cost adjustment. Standardized strips that geographic adjustment out of the payment, so it is the column to use when comparing states — a difference there reflects how the code was billed, not what it costs to run a practice locally.

State	Services	Allowed	Standardized pmt	Providers
Arizona	15,189	$102.05	$83.19	16
California	4,667	$89.47	$59.79	70
Florida	4,487	$117.18	$97.04	30
Arkansas	4,121	$35.34	$30.25	32
New York	3,302	$100.42	$74.43	52
Massachusetts	2,826	$100.67	$69.64	48
Minnesota	2,783	$62.62	$48.81	50
Texas	2,697	$102.66	$81.03	52
Ohio	2,100	$80.31	$66.95	36
Pennsylvania	1,797	$79.90	$63.01	34
Tennessee	1,399	$67.61	$57.67	27
Illinois	1,161	$62.90	$47.94	29
Utah	1,034	$95.94	$75.06	11
North Carolina	883	$69.31	$57.59	22
Washington	824	$81.32	$58.10	20
Wisconsin	763	$91.36	$72.79	20
Connecticut	627	$96.42	$75.25	9
Missouri	623	$84.49	$66.64	19
Maryland	603	$75.68	$56.33	10
Alabama	502	$66.13	$57.20	16
Oklahoma	482	$61.55	$50.69	4
Virginia	468	$94.65	$76.35	10
Michigan	383	$55.49	$42.59	14
Indiana	377	$64.86	$52.44	7
Georgia	359	$70.74	$56.27	8
South Carolina	352	$51.59	$44.38	3
Oregon	332	$68.09	$46.75	7
Louisiana	280	$48.52	$42.69	10
Iowa	276	$50.11	$42.13	6
District of Columbia	176	$37.79	$27.14	4
Nebraska	173	$32.99	$25.56	5
New Jersey	151	$36.27	$27.08	3
Kansas	116	$33.99	$26.81	4
Hawaii	116	$112.47	$76.78	2
Vermont	97	$33.75	$26.79	5
Colorado	85	$131.30	$99.99	4
Kentucky	64	$129.38	$113.01	2
New Mexico	41	$135.94	$117.11	1
West Virginia	37	$86.13	$66.18	2
North Dakota	35	$34.21	$25.07	1
Montana	31	$33.22	$26.36	1
Idaho	26	$33.95	$22.90	1
Rhode Island	26	$34.84	$27.03	1
New Hampshire	22	$32.38	$27.75	1
Maine	19	$102.35	$90.07	1

Related codes

88305Pathology examination of tissue$50.75
88341Special stained specimen slides to examine tissue$40.33
88342Special stained specimen slides to examine tissue$58.61
88313Special stained specimen slides to examine tissue including interpreta$43.56
88312Special stained specimen slides to identify organisms including interp$75.82
88307Pathology examination of tissue$84.93
88304Pathology examination of tissue$21.25
88360Microscopic genetic analysis of tumor$59.67
88311Preparation of tissue for examination by removing any calcium present$12.68
88331Pathology examination of specimen during surgery$72.30
88350Antibody evaluation$59.99
88344Special stained specimen slides to examine tissue$100.56

Billing this code is not the same as earning it

An allowed amount is revenue to a practice, not income to a clinician. It funds staff, premises, equipment and supplies before anyone is paid. What clinicians actually earn is published separately by the Department of Labor, and what industry pays them is published separately again by CMS — this site carries both.

What doctors are paid →·Look up a clinician →·All procedure codes →

Where this comes from. CMS Medicare Physician & Other Practitioners, by Provider and Service, 2024. It covers fee-for-service Original Medicare Part B only — not Medicare Advantage, not Medicaid, and not commercial insurance, which typically pays more for the same code.

How it is averaged. CMS publishes one average per provider per code. Every figure here is re-weighted by the number of services, so a clinician who billed the code 4,000 times counts 4,000 times more than one who billed it twice. CMS also suppresses any provider-code pair with fewer than 11 beneficiaries, so low-volume practice is missing from these totals by design.