How much does Medicare pay for CPT 81333?

Medicare allowed an average of $134.26 per service and paid $134.26 of that, the balance being the patient's coinsurance and deductible (2024 data). Providers submitted an average of $147.71, which is what they billed rather than what they received — Medicare pays its fee schedule regardless of the charge.

What is CPT code 81333?

Gene analysis (transforming growth factor beta-induced) for common variants. It was billed 6,758 times to 6,735 Medicare beneficiaries by 19 providers in 2024.

Which specialty bills 81333 most?

Clinical Laboratory, with 6,758 services from 19 clinicians.

CPT 81333

Gene analysis (transforming growth factor beta-induced) for common variants

$134.26Medicare-allowed amount per service, averaged across 6,758 services

Providers submitted

$147.71

Asking price, not received

Medicare allowed

$134.26

The fee schedule figure

Medicare paid

$134.26

Balance is patient coinsurance

Providers submitted an average of $147.71 for this code and Medicare allowed $134.26 — 1.1× less. That gap is normal and means nothing on its own: Medicare pays its fee schedule regardless of what is billed, so the submitted figure describes a hospital chargemaster, not a price anyone paid. Of the allowed amount Medicare paid $134.26 (100%); the rest is the patient’s coinsurance and deductible.

Services: 6,758
Beneficiaries: 6,735
Providers billing it: 19
Total allowed: $907,329

What Medicare pays for CPT 81333

Across 6,758 services billed by 19 providers to 6,735 beneficiaries, Medicare allowed an average of $134.26 per service. The allowed amount is the figure that matters: it is what Medicare and the patient together owe, set by the fee schedule and adjusted for local practice costs. What a provider chose to submit has no bearing on it.

Who bills 81333

Specialty	Services	Beneficiaries	Avg allowed	Providers
Clinical Laboratory	6,758	6,735	$134.26	19

81333 reimbursement by state

Two different numbers. Allowed is what Medicare actually allowed in that state, which includes the local practice-cost adjustment. Standardized strips that geographic adjustment out of the payment, so it is the column to use when comparing states — a difference there reflects how the code was billed, not what it costs to run a practice locally.

State	Services	Allowed	Standardized pmt	Providers
Florida	3,757	$134.26	$134.26	6
Texas	2,399	$134.26	$134.26	7
Louisiana	305	$134.26	$134.26	1
Colorado	223	$134.26	$134.26	1
Maryland	27	$134.26	$134.26	1
Oklahoma	22	$134.26	$134.26	1
Mississippi	13	$134.26	$134.26	1
New Jersey	12	$134.26	$134.26	1

Related codes

81339Gene analysis (mpl proto-oncogene$180.81
81307Gene analysis (partner and localizer of brca2) full sequence analysis$661.26
81321Gene analysis (phosphatase and tensin homolog)$586.31
81317Gene analysis (postmeiotic segregation increased 2 [s cerevisiae]) ful$662.97
81325Gene analysis (peripheral myelin protein 22)$753.85
81345Gene analysis (telomerase reverse transcriptase) targeted sequence ana$181.48
81334Gene analysis (runt related transcription factor 1) targeted sequence$322.92
81309Gene analysis (partner and localizer of brca2) targeted sequence analy$269.32
81312Gene analysis (poly[a] binding protein nuclear 1) for abnormal alleles$132.54
81320Gene analysis (phospholipase c gamma 2) for common variants$285.53
81302Gene analysis (methyl cpg binding protein 2) full sequence analysis$516.68
81374Hla class i typing$72.72

Billing this code is not the same as earning it

An allowed amount is revenue to a practice, not income to a clinician. It funds staff, premises, equipment and supplies before anyone is paid. What clinicians actually earn is published separately by the Department of Labor, and what industry pays them is published separately again by CMS — this site carries both.

What doctors are paid →·Look up a clinician →·All procedure codes →

Where this comes from. CMS Medicare Physician & Other Practitioners, by Provider and Service, 2024. It covers fee-for-service Original Medicare Part B only — not Medicare Advantage, not Medicaid, and not commercial insurance, which typically pays more for the same code.

How it is averaged. CMS publishes one average per provider per code. Every figure here is re-weighted by the number of services, so a clinician who billed the code 4,000 times counts 4,000 times more than one who billed it twice. CMS also suppresses any provider-code pair with fewer than 11 beneficiaries, so low-volume practice is missing from these totals by design.